Liver conditions in all three disease models were worsened when the mice lacked stomach acid. The team blocked stomach acid in the mice either by genetically deleting the gene that controls stomach acid secretion or by administering the PPI omeprazole (Prilosec). Results were published on Octoin Nature Communications. The study was funded in part by NIH’s National Institute on Alcohol Abuse and Alcoholism (NIAAA). Bernd Schnabl at the University of California San Diego School of Medicine looked at PPIs in mouse models of three types of liver disease-alcohol-induced liver disease, NAFLD, and NASH-and in humans. To investigate whether blocking stomach acid affects chronic liver disease, a team led by Dr. These bacteria can move to the liver and affect its function. In mice, some common acid reflux medications promote growth of Enterococcus bacteria, shown here artificially glowing red, in the intestines. However, the impact of these medications on liver disease progression has been unknown. PPIs are often used by people who have chronic liver disease. So can a commonly used class of heartburn medication called proton pump inhibitors (PPIs), which block stomach acid secretion. Misusing alcohol alters the microbes in your gut. But alcohol misuse accounts for about half of cirrhosis-related deaths.Ĭhanges in your gut’s microorganisms, or microbiota, can affect the progression of liver disease. Many conditions can contribute to the development of cirrhosis, including obesity, which is associated with non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH), a form of NAFLD in which you also have inflammation and liver cell damage. Liver cirrhosis is a leading cause of death worldwide. Scarring of the liver may lead to cirrhosis, a condition in which the liver is unable to function normally. However, repeated or long-lasting injury can cause scar tissue to form. The liver can regenerate after being damaged. A healthy liver is necessary for survival. The liver has many important functions, including helping to digest food and process and distribute nutrients. New research suggests certain kinds may have an impact on chronic liver disease. The use of medications to suppress stomach acid has been on the rise.
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